Searching for a really good anti-wrinkle cream?  Here’s a look at ingredients that work for prevention and reversal .

For over 20 years , scientists have known that antioxidants had the ability to prevent free radical damage .  They also knew they had the potential to reverse the aging process .  This is particularly true with the use of natural skin care products.

Free radical damage , according to dermatologists , is one of the major causes of the many signs of aging.  Wrinkles, sagging skin, roughness, dryness, age spots , etc. 

It took lots of trials and lots of different antioxidants before before scientists finally found one that in truth worked, without causing irritation .  The easiest way to round up volunteers for the trials was to seek out persons with skin already damaged by the sun . 

The symptoms of sun damaged skin are the same as those of aging skin.  It’s just that the people who experiencing the symptoms may be a lot younger.  Sun damage is actually free radical damage.

One of the first breakthroughs that scientists had came when Tretinoin was found to be efficacious for reducing wrinkles .  Tretinoin is a man-made form of retinol, the antioxidant vitamin A .  It was first designed as a treatment for acne .

How tretinoin works to reduce wrinkles is still considered unknown .  But, scientists are pretty sure that it works because of its antioxidant activity. 

The drawbacks to the tretinoin anti wrinkle creams are several .  First, it is only available with a prescription .  Second, it is very costly .  Third, it causes redness, itching and irritation .  Some people never use it long enough to see any results .

Comparative studies show that natural forms of retinol , such as is found in avocado extract and other fruits and vegetables, are just as beneficial as tretinoin.   More importantly, the natural skin care forms do not cause any unwanted side effects.

But, scientists have found that the best antioxidant for the healing of sun-damage, wrinkles, roughness and other signs of an aged appearance is CoQ10 .  When skin care products with CoQ10 are applied topically on a daily basis for three months , sun damage is healed by thirty percent . 

The CoenzymeQ10 molecules must be reduced in size in order to make an effective anti wrinkle cream.  Nano-lipobelle HeQ10 particles are the form to look for.